Tuesday, August 31, 2010

Haiti assist bid injured by delayed U.N. reply

Tom Brown PORT-AU-PRINCE Fri Feb 26, 2010 1:13pm EST Related News Haiti preserve puncture as sleet turns camps to mudThu, Feb eighteen 2010U.N. assist arch chides agencies on Haiti reliefThu, Feb eighteen 2010Sarkozy visits Haiti, unveils vital assist packageWed, Feb seventeen 2010Tarps, toilets are priorities for quake-hit Haiti: U.N.Mon, Feb fifteen 2010One month after quake, Haitians stick on to weep deadFri, Feb twelve 2010 < 1 / 7 > People travel at a temporary tent stay in Cite Soleil in Port-au-Prince Feb 26, 2010. REUTERS/Carlos Barria

PORT-AU-PRINCE (Reuters) - Clutching involuntary attack rifles, truckloads of U.N. infantry patrolled the streets of Haiti"s cracked collateral on the day after the trembler strike last month, clearly preoccupied to the wretchedness around them.

World&&&&Natural Disasters

Cries for assistance from people digging for survivors in collapsed buildings were drowned out by the bark of heavy-duty engines as the infantry plowed by Port-au-Prince but interlude to stick on rescue efforts, majority less lead them.

A usual steer since they were deployed in 2004, the U.N. infantry huddled in the shade of their canopied vehicles.

There were about 9,000 uniformed U.N. peacekeepers stationed in Haiti when the upheaval struck on Jan twelve and they were the judicious "first responders" to the mess in the bankrupt Caribbean country, whose notoriously diseased executive supervision was impressed by the scale of the tragedy.

Initially, however, nothing of the peacekeepers appeared to be concerned in hands-on charitable service in what puncture healing experts report as the vicious initial 72 hours after a harmful trembler strikes.

Their reply to the abominable pang was singular to you do security and seeking for looters after the bulk 7.0 upheaval intended majority of the collateral and took what Haitian President Rene Preval says could be as majority as 300,000 lives.

There was looting in the capital, but it paled in some-more aged with the astringency of the charitable crisis.

Horribly-injured patients flooded overstretched hospitals, forcing healing staff to confirm that patients to yield and that were already as well far left to try saving.

"Doctors played God," pronounced Tyler Marshall, a maestro former Los Angeles Times match operative with an general assist organisation that helped out in a tent city erected at the tallness of the destruction on the drift of Port-au-Prince"s University Hospital, the country"s largest.

Scores of U.N. crew died in the quake, together with Hedi Annabi, head of the U.N. mission that was set up in 2004. That helps insist what majority have criticized as a glacially delayed kickoff of service operations after one of history"s misfortune healthy disasters.

But in the days and weeks that followed it mostly seemed that lessons from alternative disasters were abandoned in Haiti as fears of rioting or anarchy overshadowed concerns about removing assist out quickly.

The U.N."s tip charitable assist official, John Holmes, is between those who have chided service agencies, together with the United Nations itself, for you do as well small to assistance Haiti.

"We cannot ... wait for for for the subsequent puncture for these lessons to be learned," Holmes wrote in a trusted email initial published on the website of the biography Foreign Policy.

"There is an obligatory need to progress significantly genius on the ground, to urge coordination, vital formulation and sustenance of aid," pronounced Holmes.

Edmond Mulet, behaving head of the U.N. mission, concurred in an talk that it played a singular charitable purpose in the initial couple of days after the trembler since the operations were effectively decapitated.

"At the unequivocally commencement it was unequivocally formidable since all the domicile was utterly broken and all the care of the mission was killed," Mulet told Reuters.

"CRIMINALS AND BANDITS"

Mulet gained prominence for wielding an iron fist during a prior army as head of the U.N. mission when he led mostly Brazilian "blue helmet" infantry in a successful crackdown on Haiti"s heavily armed gangs.

And he has finished no tip about sophistry the competing needs of service operations with law enforcement, in his bid to lane down the some-more than 3,000 inmates who took value of the trembler to shun from the main prison.

"We are here additionally to yield security," he pronounced when asked about the mess of convoys of rifle-wielding U.N. infantry to poke for people trapped in the rubble of the busted capital.

"I still have to patrol, I still have to go after all these criminals and bandits that transient from the inhabitant penitentiary, the squad leaders, the criminals, the killers, the kidnappers. I cannot unequivocally confuse myself from you do that."

The service mission shifted in to higher rigging after U.S. infantry deployed in large numbers and set up a supply sequence to get food and disinfectant in to areas great out for aid.

But there were still majority bottlenecks and setbacks, mostly involving U.N.-linked food distributions hobbled by unsound organization, reserve and throng control.

Unfortunately, U.N. infantry in Haiti have over the years gained a repute for toughness and abuse some-more than for easing pang in the lowest nation in the Americas.

"The usually time I"ve seen one of these U.N. infantry burst out of the behind of a lorry was to kick up on somebody or take a shot at them," pronounced a piece of the U.S. Army"s 82nd Airborne Division, as he worked security during a new assist handout.

"These guys have since all of us in unvaried a bad repute here," he said, asking not to be identified.

Haiti"s wrecked infrastructure and bad ride links finished it formidable to get assist out and keep it flowing, but that frequency finished the incident opposite from that in alternative new disasters around the globe.

"POOREST AND MOST VULNERABLE"

"The lowest and the majority exposed people lend towards to live in the regions that are strike the majority by healthy disasters," pronounced Solomon Kuah, an puncture healing medicine formed in New York who outlayed 4 weeks in Port-au-Prince after the quake.

There are no arguable estimates for the series of survivors who died from injuries due to unsound healing supplies.

But Henriette Chamouillet, the World Health Organization"s deputy in Haiti, pronounced all from staff shortages to bureaucracy and a miss of make-up lists embroiled the smoothness of containers full of medicines from Port-au-Prince"s airfield to doctors on the ground.

Port-au-Prince sits usually 700 miles off the seashore of Miami, that is home to a large Haitian-American community, and it seemed ludicrous that so couple of the U.S. infantry rushed there spoke French or were accompanied by translators.

One retaining picture of pell-mell food distributions came when U.S. helicopters offloaded boxes of MREs (Meals Ready to Eat) at a site in the capital. Many Haitians non-stop them up usually to toss them afar in offend since no French or Creole-language instructions were enclosed with the assumingly invalid packets of dust, explaining that they indispensable to be churned with H2O as piece of their preparation.

Rajiv Shah, head of the U.S. Agency for International Development, has touted the Haiti service mission as "the largest and majority successful general poke and rescue bid ever fabricated in history."

But some-more than 6 weeks after the upheaval hit, the mission is still mostly in an puncture reply mode. The U.N."s World Food Program is tying the food rations to 55-pound (25 kg) bags of rice and the Haitian supervision estimates that a million upheaval survivors are still vital in the streets in temporary encampments with no using H2O or toilets.

Doctors are roughly finished traffic with dire injuries but reconstruction for a little 40,000 amputees and rebuilding Haiti"s health infrastructure are between long-term challenges.

"This is unequivocally a mess of Biblical proportions," pronounced Lewis Lucke, who was the USAID executive in Iraq prior to entrance to Haiti as U.S. ambassador.

U.N. and alternative officials have pronounced the tellurian reply to Haiti"s upheaval was quicker and some-more in effect than in alternative new disasters, together with the Asian tsunami that killed 226,000 people in thirteen countries in Dec 2004.

But experts contend the United Nations has a lot to sense from smaller, some-more nimble healing groups similar to International Medical Corps, or IMC, and Paris-based Medicins Sans Frontieres, along with charities some-more experienced in distributing aid, such as CARE and Catholic Relief Services.

Kuah, who concurrent service efforts for IMC, a California-based organisation that had rarely learned doctors treating patients in Haiti twenty-three hours after the trembler struck, stressed the "need for speed" when it comes to saving lives.

"When you ask yourself if there were ways you could have prevented some-more mortalities or discontinued additional mortality, with earthquakes, in particular, it"s some-more timing than anything else," pronounced Kuah.

(Additional stating by Catherine Bremer, Jackie Frank, Patricia Zengerle, Mica Rosenberg and Andrew Cawthorne; Editing by Kieran Murray)

World Natural Disasters

Sunday, August 29, 2010

Triangle Capital sees income climb

Triangle Capital Corp. generated $4 million in net investment income in the fourth quarter, a 37 percent enlarge from a year ago.

The Raleigh investment organisation benefited from a incomparable investment portfolio. Triangle Capital creates loans to midsize, secretly hold businesses, whilst receiving a minority tenure interest in the portfolio companies.

Triangle Capital done 3 new investments totaling $23 million in the fourth quarter. For the complete year, it done 7 investments totaling $43 million, and one more loans and equity investment in portfolio companies.

Staff bard David Ranii

Saturday, August 28, 2010

REUTER MONEYGRAPH-IMF SDR RATES-Apr 9 US 1.51661

Fri April 9, 2010 4:38pm EDT

APR 09 APR 08 APR 09 APR 08U.S. 1.51661 1.51343 IRANIAN N/A 15208.50EURO 1.13315 1.13826 KUWAIT N/A 0.43716U.K. 0.98744 0.99424 NORWEGIAN 8.99321 9.04969AUSTRALIA 1.63515 1.63173 S. AFRICAN 11.0561 11.1010JAPANESE 141.879 141.309 SWEDISH 10.9461 11.0367CANADIAN 1.52495 1.51646 SWISS 1.62368 1.62830DANISH 8.43398 8.47292 SAUDI 5.68728 5.67537CLICK ON USLD16 FOR FULL LIST OF SDR RATES UPDATED DAILY

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Friday, August 27, 2010

Liverpool have suffered from a miss of investment says Rafael Benitez Football

Tim Meston & ,}

Rafael Benitez has come out in agreement with Fernando Torres over the striker"s straightforward comment of Liverpool"s failings this season.

Torres believes that the disaster to sufficient reinstate Xabi Alonso, Alvaro Arbeloa and Sami Hyypia has valid rarely deleterious to the bar that lost just twice last deteriorate in finishing runners-up in the Premier League to Manchester United.

A pull at Birmingham City on Sunday has left Liverpool sixth, 4 points adrift of the last Champions League-qualifying position, carrying played a game some-more than both Manchester City in fourth and Tottenham Hotspur in fifth.

Benitez concedes his patrol needs vital investment this summer to force the approach back between the pretension contenders. "I determine with Fernando about a lot of things," he said. "He talks about it being a empathize we accomplished with 86 points last year and we couldn"t progress.

Related LinksSummer sales shop-worn us, says TorresBenitez defends preference to take off TorresBenitez fears for Aquilani"s state of mind

"We need to pointer a little players, we need to move a little money. We need an investor and afterwards we can plea in a improved way.

"The players are operative so tough and they feel they can do more. Fernando the alternative day [at Birmingham], he was feeling unequivocally tired. He was perplexing and the alternative players were perplexing but whilst we don"t have the financier it will be formidable to go one step forward."

Liverpool host Benfica at Anfield tomorrow in the second leg of their Europa League quarter-final, with Benitez"s group trailing 2-1 after the initial leg.

"We will try to do the most appropriate tomorrow to win," Benitez said. "Hopefully we can change the books this year. We need right away to perform on the representation and create a improved incident for the new investors.

"We are you do unequivocally well at home, generally the last games in the league and Europa League.

"We are assured we can kick Benfica. We have an event right away to win silverware so it will be critical right away for all the people here, for the fans and the club.

"The fans subsidy the group is the most appropriate approach to get a outcome so I goal they will be at the back of the team."

Torres is fit after being seen with an ice pack on his knee following his substitution at Birmingham but Ryan Babel and Emiliano Insua are suspended.

Thursday, August 26, 2010

PREMIER LEAGUE LIVE Follow the movement from Birmingham Chelsea Hull Tottenham West Ham and Wolves

SCORES

Birmingham 1-1 Arsenal FT

Chelsea 7-1 Aston Villa FT

Hull 2-0 Fulham FT

Tottenham 2-0 Portsmouth

West Ham 0-1 Stoke FT

Wolverhampton 0-0 Everton FT

Bolton v Man Utd, 17:30

LATEST

17.00 Result of the day

FL2 Shrewsbury 0 Darlington 2

GOAL! Birmingham 1 (Kevin Phillips 90) Arsenal 1

A weird and a produce blow for Arsenal. Sagna"s clearway set upon Phillips in the face and rebounded over Almunia.

GOAL! Chelsea 7 (Frank Lampard 90) Aston Villa 1

16.52 Bolton v Man Utd teams

Bolton: Jaaskelainen, Ricketts, Cahill, Knight, Samuel, Muamba, Lee, Cohen, Wilshere, Elmander, Kevin Davies. Subs: Al Habsi, Taylor, Riga, Mark Davies, Klasnic, Andrew O"Brien, Weiss.

Man Utd: Van der Sar, Neville, Vidic, Jonathan Evans, Evra, Fletcher, Scholes, Valencia, Giggs, Nani, Berbatov. Subs: Kuszczak, Park, Carrick, Rafael Da Silva, Macheda, Gibson, De Laet.

Referee: Martin Atkinson (W Yorkshire)

GOAL! Birmingham 0 Arsenal 1 (Samir Nasri 81)

Wonderful run and set upon from Nasri, who picked up the round on median and ran on to unleash a right-footed expostulate in to the far corner.

GOAL! Chelsea 6 (Salomon Kalou 83) Aston Villa 1

Villa have left to pieces. Embarrassing. Anelka authorised to set up Kalou to cadence a first-time shot past Friedel.

16.38 Injury blow for Pompey

Hreidarsson fell awkwardly at a Spurs dilemma and was in the future carried off on a stretcher, receiving gas for the suffering with his ankle strapped in a protecting cast.

GOAL! West Ham 0 Stoke 1 (Ricardo Fuller 69)

Zola has twenty mins to save his job. His screw Green couldn"t do anything to keep out Fuller"s overwhelming strike.

GOAL! Chelsea 5 (Florent Malouda 68) Aston Villa 1

It"s a rout. Chelsea"s unconditional move down the right accomplished with Malouda rifling the round in to the net.

16.21 Birmingham set upon the post

Arsenal unresolved on. Johnson set upon the post and Dann spooned the miscarry over from dual yards

GOAL! Chelsea 4 (Frank Lampard Pen 62, Hat-trick) Aston Villa 1

Lampard"s fifth career hat-trick. The midfielder scored from the mark after Dunne hauled down Zhirkov.

GOAL! Chelsea 3 (Florent Malouda 57) Aston Villa 1

Villa are dominant this year but Malouda has been in a abounding capillary of form and he swept home a cranky from Zhirkov.

GOAL! Hull 2 (Craig Fagan 48) Fulham 0

The Hammers fans who believed Hull were passed and buried will be starting to flounder in their seats. Dean Marney"s cranky from the left was met at the far post by Craig Fagan and his header looped over Mark Schwarzer.

16.05 The games have restarted

HT: Chelsea 2-1 Aston Villa

Arsenal were anticipating the going tougher opposite Birmingham at St Andrew"s.

Arsene Wenger"s men had the most appropriate possibility when Theo Walcott was sealed down in the box by Blues goalkeeper Joe Hart, but were incompetent to find a breakthrough.

HT: Hull 1 Fulham 0

Hull rode their fitness to lead at half-time of their consequential BarclaysPremier League strife opposite Fulham at the KC Stadium interjection to Jimmy Bullard"spenalty.

Chris Smalling hauled down Jozy Altidore 6 yards out and former Fulhammidfielder Bullard silenced the boos of the on vacation supporters with a confidentstrike in to the tip corner.

But the home side, seeking to finish a run of five true defeats, twice had toclear off their own goal-line, with Zoltan Gera denied initial by George Boatengand afterwards Steven Mouyokolo.

HT: West Ham 0 Stoke 0

West Ham"s Barclays Premier League presence hopes grew ever bleaker asthey were hold to a goalless first-half by Stoke.

Abdoulaye Faye longed for dual great chances for Stoke and Mido blundered whenpresented with a golden event for West Ham after a extreme set upon fromCarlton Cole.

With Hull violence Fulham at half-time, West Ham knew a pull would not be enoughto stop them being dragged closer to the relegation zone.

HT: Tottenham 2 Portsmouth 0

Peter Crouch headed Tottenham in to the lead opposite his former clubPortsmouth at White Hart Lane, prior to Niko Kranjcar done it 2-0 only prior to thebreak.

Spurs, chasing a top-four finish, proposed slowly, but went forward when Crouchnodded in a low cranky from Gareth Bale.

Bottom bar Pompey - who will face Spurs in the FA Cup semi-final at Wembley -should have been in front, but Anthony Vanden Borre unsuccessful to flog the keeperwhen purify through.

HT Wolves 0 Everton 0

Louis Saha set upon the woodwork and Leon Osman spurned 3 goodopportunities as Everton enjoyed the improved chances opposite Wolves at Molineux.

Everton, creation a late European assign after losing only dual of seventeen BarclaysPremier League games, found themselves out of fitness in front of idea in ascoreless initial half.

Yet the Merseysiders were never in finish carry out as Wolves enjoyed goodpossession but formulating most definite chances.

HT: Chelsea 2 Aston Villa 1

A first-half prop from Frank Lampard gave Chelsea the value againstAston Villa at Stamford Bridge.

Chelsea went forward in the 15th notation when Frank Lampard converted a low cranky from Florent Malouda at the far post. But in-form John Carew grabbed his ninth idea in eight games when he accomplished off a curling cranky from Ashley Young.

Lampard easy Chelsea"s lead from the chastisement mark in the 44th notation afterYury Zhirkov had been brought down by James Collins.

GOAL! Chelsea 2 (Frank Lampard Pen 44) Aston Villa 1

Collins tripped Zhirkov in the box and Lampard slammed his mark flog in to the tip dilemma for his second idea of the game.

Quake tsunamis kill some-more than 700 in Chile

Mario Naranjo CONCEPCION, Chile Sun Feb 28, 2010 6:10pm EST Factboxes Factbox: Chile upheaval hits copper mines, ports and refineriesSun, Feb twenty-eight 2010Factbox: Chile upheaval hits copper mines, ports and refineriesSun, Feb twenty-eight 2010Factbox: Chile upheaval hits copper mines, ports and refineriesSun, Feb twenty-eight 2010 Related News Copper seen up as upheaval hits tip writer ChileSun, Feb twenty-eight 2010Chile to restart greatest copper mines strike by quakeSun, Feb twenty-eight 2010Earthquake to draw towards on Chile retrogression recoverySun, Feb twenty-eight 2010 Related Video Video Looting erupts in quake-hit Chile Sun, Feb twenty-eight 2010 Assessing the repairs in Chile Chile upheaval held on camera < 1 / 29 > Residents redeem equipment from the waste left by waves generated by a vital earthquake, circuitously the epicenter in Pelluhue Feb 28, 2010. REUTERS/Ivan Alvarado

CONCEPCION, Chile (Reuters) - A large trembler and tsunamis killed 350 people in one Chilean coastal town, doubling the sum genocide fee on Sunday as the supervision attempted to get assist to inspired survivors and hindrance looting.

World&&&&Natural Disasters

President Michelle Bachelet pronounced at slightest 708 people had been killed and called for ease as people unfortunate for food and H2O looted stores in a little areas misfortune strike by Saturday"s 8.8-magnitude quake, one of the world"s greatest in a century.

Television images showed houses cleared afar by swirling waters, cars tossed in to cracked buildings and boats carried in to the streets in coastal towns together with Pelluhue and Constitucion, where 350 deaths alone were reported.

"It"s an huge disaster ... there"s a flourishing series of blank people," Bachelet said, adding that food and healing assist was being sent to assistance the rounded off 2 million people influenced by the quake.

The upheaval wrecked hundreds of thousands of homes, deformed highways and bridges and dealt a complicated blow to infrastructure in the world"s No. 1 copper writer and one of Latin America"s majority fast economies.

Giant waves set off by the upheaval crashed hundred of meters in to a little coastal towns and villages circuitously the epicenter, demolishing houses and promulgation residents journey in to the hills. The supervision had told Chileans rught away after the upheaval that there was no risk of a tsunami, an blunder it pronounced was formed on improper interpretation from armed forces experts.

"I"ve got zero left but what I"m wearing. We ran desperately up the mountain and watched how the sea cleared all away," an unclear lady from the fishing encampment of Duao told state television.

A miss of water, food and fuel sensory the hard times for the hundreds of thousands of people left homeless, and drawn out intrusion to the energy supply in jeopardy to bushel Chilean industry"s recovery.

Chile"s greatest copper mines influenced by the upheaval solemnly resumed operations on Sunday notwithstanding singular energy supplies, that analysts contend could diminish exports.

In the hard-hit city of Concepcion, about 310 miles south of Santiago, about 60 people were feared to have been dejected to genocide in a collapsed unit retard where rescuers worked by the night to find survivors.

The supervision imposed a night curfew in Concepcion and the Maule segment in a bid to stop looting and armed forces infantry began to arrive in the city late on Sunday.

Police used rip gas and H2O cannons to sunder a throng of looters carrying off food and electrical appliances from one supermarket in Concepcion. Television images showed people seasoned mixture groceries and alternative products in to selling trolleys.

"People have left days but eating," pronounced Orlando Salazar, one of the looters at the supermarket. "The usually choice is to come here and get things for ourselves."

Concepcion"s mayor, Jacqueline outpost Rysselberghe, pronounced the incident was removing "out of control" due to shortages of simple reserve and called for infantry to be sent to the city.

AFTERSHOCKS

The upheaval poses a daunting reformation plea for President-elect Sebastian Pinera, who takes bureau in dual weeks.

Crushed cars, depressed energy lines and rubble from wrecked buildings dirty the streets of Concepcion, that has about 670,000 inhabitants and lies 70 miles southwest of the quake"s epicenter.

A fibre of clever aftershocks have rocked the nation and thousands of Concepcion residents camped out in tents or temporary shelters, fearing uninformed tremors could disintegrate enervated buildings.

Some economists likely a low stroke on Chile"s economy after the upheaval shop-worn the industrial and rural sectors in the worst-hit regions, presumably putting vigour on the currency.

The mercantile repairs from the upheaval could be up to $30 billion, homogeneous to about fifteen percent of Chile"s sum made at home product, pronounced Eqecat, a organisation that helps insurers indication disaster risks.

Chile"s fourth-largest copper cave El Teniente, that accounts for some-more than 7 percent of inhabitant output, resumed operations on Sunday. The circuitously Andina cave was additionally due to resume operations but analysts feared energy outages could still diminish supplies.

Production additionally resumed on Sunday at the Anglo-American Los Bronces copper mine, one of the company"s dual mines where energy outages halted output, a kinship personality told Reuters.

Santiago"s airfield proposed to embrace general flights for the initial time given the upheaval struck. Officials pronounced the runways were protection but the depot construction was damaged.

The earthquake triggered tsunamis as far afield as Japan and Russia, but there were no evident reports of injuries or critical damage.

(Additional stating by Simon Gardner and Alonso Soto in Santiago and London bureau; Writing by Stuart Grudgings and Helen Popper, modifying by Anthony Boadle)

World Natural Disasters for acne doctors to help adolescents to treat their acne

Monday, August 23, 2010

Camerons hoped modelling photos would not resurface

David Cameron has certified he hoped risque photos of mother Samantha modelling would never come to light.

The pictures, taken some-more than a decade ago, shortly after the integrate married, show Mrs Cameron in a accumulation of outfits, draped opposite sofas and rolling on the building with a kitten.

The conform and sell senior manager assumingly concluded to poise as a foster to a crony who written the clothes.

Mr Cameron told reporters this sunrise that the integrate were both really suprised when the photos flush in the Mail on Sunday.

She did these cinema a prolonged time ago in tie with her business, I think behind in 1996 or 1997, he said.

But we knew one day someone competence recollect them. We were anticipating they would never appear, but they have. These things happen.

Thursday, August 19, 2010

Novel medicine plan grown utilizing tagged contracting agents

A Tufts-led group grown the new plan to broach small contracting agents that find out Botulinum venom molecules and connect to them at multiform points. The contracting agents each enclose a usual tab that is famous by a single, co-administered anti-tag antibody. Once the venom proton is surrounded by firm antibodies, it is burning out of the complement by the liver prior to it can poison the body.

Botulinum toxin, that causes botulism, is the majority acutely unwholesome piece well known and is deliberate between the majority dangerous bioterrorist threats. Studies have shown that one gram of the toxin, that is constructed by a micro-organism that lives in soil, could kill upwards of a million people. Although now accessible antitoxins can be mass constructed and delivered in the eventuality of an outbreak, they are dear to develop, residence and broach -- and have a short shelf-life.

The Tufts study, in partnership with researchers at Thomas Jefferson University in Philadelphia, is published this month in the biography Infection and Immunity and was saved by the National Institutes of Allergy and Infectious Diseases (NIAID) and the New England Regional Center for Excellence (NERCE) for Biodefense and Emerging Infectious Diseases.

We"ve proven this proceed to strengthen opposite Botulinum intoxication in mice and we goal this will lead to fast growth and deployment of most new anti-toxin therapies -- for botulism and beyond, pronounced Charles B. Shoemaker, PhD, highbrow of biomedical sciences at Tufts UniversityCummings School of Veterinary Medicine and the studycorresponding author.

The new commentary enhance on a 2002 new thing at the University of California at San Francisco, where scientists total 3 monoclonal antibodies opposite Botulinum venom that trustworthy to opposite tools of the venom molecule. Including 3 opposite antibodies dramatically increasing the potential compared to fewer antibodies and prevented intoxication even following high-dose exposure. However, developing, producing, and stockpiling 3 opposite monoclonal antibodies opposite each venom sort is really expensive.

Instead of utilizing 3 antibodies, the Tufts proceed uses 3 small contracting agents to approach a singular monoclonal antibody to mixed sites on the biomolecule being targeted for clearance. The sort of contracting agents used can be comparison from most scaffolds grown for blurb healing applications (e.g. nanobodies, aptamers, darpins, FN3, microbodies, etc). These contracting agents can be fast identified and softened utilizing complicated technologies and in all have glorious blurb prolongation and product shelf-life properties. The singular anti-tag monoclonal antibody can additionally be comparison to have optimal isotype and commercialization properties.

Whatmore, the contracting agents can be constructed with some-more than one tag, that enables them to approach some-more antibodies to the venom -- and synergistically urge aim clearway from the body. Many contracting representative scaffolds can be constructed as organic multimers so that the opposite contracting agents could be constructed as beads on a string, heading to a singular proton that targets one, or even several, biomolecules for clearway from the body.

Using this approach, the researchers say, one would customarily need to emanate new contracting agents, not new antibodies, to emanate a caring to transparent a venom from the physique -- paving the approach for new therapies that fight toxins trimming from animal venom to bioterrorist agents such as ricin. Tufts researchers are now targeting Shiga venom and C. difficile along with alternative sorts of Botulinum toxin. Future plans embody targeting clearway of pathogenic cytokines that are concerned in inflammation and autoimmune diseases.

Treatment for botulism customarily requires most weeks of intensive-care hospitalization, and bearing of even a small series of people would severely interrupt health caring smoothness in any vital city, studies have indicated. A vaccine has been developed, but drawn out make use of is not now being considered, the researchers say, given the odds of bearing is uncertain. Also, vaccination would retard supposed treatments for a series of overactive flesh conditions, together with dystonias, that reply to the venom when administered in really small doses.

The Division of Infectious Diseases at the Cummings School of Veterinary Medicine is Tufts Universitylargest investigate division. In 2003, the multiplication was awarded a $25-million, seven-year stipulate from the National Institutes of Health (NIH) to rise products to fast identify, prevent, treat, and diagnose food and waterborne diseases that bluster open health. Tufts determined one of 7 inhabitant investigate units inside of the new inhabitant Food and Waterborne Disease Integrated Research Network. The endowment additionally launched the Microbiology and Botulism Research Unit, that combines botulism investigate efforts from Tufts and alternative open and in isolation institutions in the U.S. and U.K.

The multiplication additionally oversees the New England Regional Biosafety Laboratory, a 41,000 block foot, level-2 and level-3 trickery dedicated to the investigate of existent and rising infectious, diseases, toxin-mediated diseases and healing countermeasures critical to biodefense.

Wednesday, August 18, 2010

Air Pollution Slows Down Women Marathoners

Dirty air could impede the opening of women inmarathons, a new investigate finds.

Linsey Marr of Virginia Tech evaluated marathon raceresults, continue interpretation and air wickedness concentrations for 7 vital U.S.marathons in cities such as New York, Boston and Los Angeles, wherepollution tends to be highest

Multiple runnings of each marathon were evaluated, from eight to twenty-eight uninterrupted years, depending on the race.

The tip 3 masculine and womanlike finishing times were comparedwith the march jot down and contrasted with air pollutant levels, receiving hightemperatures (which can negatively stroke using performance) intoconsideration.

Higher levels of particles in the air additionally well known as fog wereassociated with slower opening times for women. Men, however, showed nosignificant stroke from pollution.

And "although wickedness levels in these marathonsrarely exceeded inhabitant standards for air quality, opening was stillaffected," Marr said.

Although the normal chairman on foot on the travel competence not besignificantly impacted by low-yet-still-acceptable air quality, marathonersare atypical since of their respirating patterns.

"Previous investigate has shown that during a race,marathon runners breathe and whisper about the same volume of air as a sedentaryperson would over the march of dual full days," Marr said. "Therefore,runners are unprotected to most larger amounts of pollutants than underneath typicalbreathing conditions."

Of the pollutants found in the air, sold make a difference (tinysolid and liquid particles, such as dust and soot, dangling in the air) seemedto be the usually sort that influenced performance. Carbon monoxide, ozone, nitrogendioxide and sulfur dioxide didnt stroke racing times for men or women.

The formula of the investigate are minute in the Mar issue ofthe biography Medicine & Science in Sports & Exercise.

Top 10 Bad Things That Are Good for You Ten Amazing Facts About Your Heart The Science of Sports

Wednesday, August 11, 2010

Film organisation continues untelevised Governors Awards

March 24, 2010, 2:38 PM EST

LOS ANGELES (AP) -- The movie academy is stability the new convention of presenting titular Oscars at an untelevised rite months prior to the Academy Awards.

Academy of Motion Picture Arts and Sciences boss Tom Sherak says the second annual Governors Awards will be hold Nov. 13. The in isolation cooking eventuality will be constructed by past academy boss Sid Ganis, Sherak pronounced Wednesday.

Some of the academy"s top honors, together with the Jean Hersholt Humanitarian Award and the Irving G. Thalberg Memorial Award, might be presented at the event. The house of governors will encounter in Aug to establish the 2010 honorees.

Lauren Bacall, Roger Corman and Gordon Willis perceived titular Oscars and John Calley was presented with the Thalberg endowment at the initial Governors Awards last year.

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Sunday, August 8, 2010

Elan sensitively gives J&J choice on Alzheimer drug

Toni Clarke BOSTON Fri Mar 12, 2010 5:19pm EST Stocks & &

BOSTON (Reuters) - Irish drugmaker Elan Corp Plc (ELN.I) has quietly given Johnson Johnson (JNJ.N) the right to acquire its 49.9 percent stake in their joint Alzheimer"s disease venture -- a move that could deter potential bidders for Elan.

Deals&&&&Inflows Outflows

The agreement, buried in Elan"s recently filed annual report, is part of a broader transaction announced last July in which JJ agreed to pay $1 billion for 18.4 percent of Elan and take a 50.1 percent stake in a new company working on Elan"s most advanced experimental Alzheimer"s drugs.

The terms of that deal were revised downwards after it emerged Elan and JJ had come to a secret -- and improper -- agreement under which JJ could gain a half share in the blockbuster multiple sclerosis drug, Tysabri, which Elan markets in a 50-50 partnership with U.S. biotech company Biogen Idec Inc (BIIB.O).

Now, it emerges Elan not only gave JJ an option on Tysabri, it also gave the company an option to acquire its 49.9 percent stake in Janssen Alzheimer Immunotherapy, the subsidiary formed by JJ to acquire Elan"s Alzheimer"s Immunotherapy Program (AIP). The unit includes bapineuzumab, Elan"s most advanced experimental Alzheimer"s drug.

"Many large shareholders are up in arms about this," said Larry Feinberg, who runs Oracle Investment Management and holds 5 million Elan shares. "Elan has one of the best neuroscience businesses in the world, but now Biogen has right of first refusal on Tysabri and JJ has right of first refusal on bapineuzumab. It"s something that will get in the way of a potential acquirer."

Discussion of a possible buyer for Elan is far from academic. The company is one of research firm Morningstar"s top 10 likely acquisition targets.

Biogen, whose standstill agreement with Elan expires in June, has long been considered the most logical suitor for Elan as the relationship between them -- each has the right to acquire the other"s share of Tysabri should there be a change of control at either company -- represents a hurdle to potential third-party acquirer .

But Elan concedes its agreement with JJ on bapineuzumab could have a similarly chilling effect.

"We are party to agreements that may discourage a takeover attempt that might be viewed as beneficial to our shareholders," the company said in its annual report, listing as examples its Tysabri agreement and the newly revealed Alzheimer"s drug agreement with JJ.

Elan did not directly respond to an email asking why it did not disclose the matter when the transaction was announced. Bob Purcell, a company spokesman, said only that "change of control clauses are a standard part of any asset transaction within the pharmaceutical industry."

A potential Elan acquirer would get either a non-controlling financial interest in Janssen AI or the cash equivalent to its fair value, he said.

Karen Andersen, an analyst at Morningstar, said the agreement should have been reported at the time.

"I think this is material information," she said. "I think this should have been volunteered and discussed when they had their conference calls to discuss the deal, rather than putting us in a position of digging for it later."

Bapineuzumab is being developed in conjunction with Pfizer Inc (PFE.N), which took the drug over when it acquired Wyeth. Pfizer currently has a 50 percent stake in the partnership, while JJ and Elan have roughly 25 percent each. If JJ exercises its option -- which would kick in if Elan were to be acquired -- it would gain Elan"s share.

Some investors have written off bapineuzumab because it showed mixed results in a mid-stage clinical trial. But Alzheimer"s disease, a degenerative condition that robs victims of memory, afflicts 26 million people worldwide and, if bapineuzumab turns out to be successful, it could generate billions of dollars in revenue.

The company"s delay in disclosing the Alzheimer"s option is particularly galling to investors, given its side agreement with JJ on Tysabri last year landed Elan in court.

In that case, a U.S. federal court judge ruled Elan breached its contract with Biogen, prompting Elan to withdraw the Tysabri option from its deal with JJ. JJ, in response, cut the amount it would pay for its Elan stake by $115 million to $885 million.

Elan"s shares have fallen 13 percent to $7.45 from a 12-month high of $8.58 at the time the original transaction was announced on July 2.

(Reporting by Toni Clarke; editing by Andre Grenon)

Deals Inflows Outflows

Thursday, August 5, 2010

U.S. gamble AIG units would cost higher -- and won

Paritosh Bansal and Kristina Cooke NEW YORK Thu Mar 4, 2010 8:28am EST Related News Prudential and AIG CEOs hold "town hall" meetingsThu, Mar 4 2010UPDATE 1-Pru, AIG CEOs meet Asia staff; talk AIA future, jobsThu, Mar 4 2010UK"s Pru to buy AIG Asia unit for $35.5 billionMon, Mar 1 2010UK"s Pru to buy AIG Asia unit for $35.5 blnMon, Mar 1 2010AIG agrees to $35.5 billion unit sale to Prudential: sourcesSun, Feb 28 2010 Stocks & &

NEW YORK (Reuters) - American International Group Inc (AIG.N) Chief Executive Robert Benmosche, typically in the position of playing defense for one of America"s most vilified companies, recently got a taste of what it must have been like when the insurer was a world-beating empire.

Deals

Benmosche, thanks to a spectacular reversal of fortunes that has been engineered by the U.S. government, was able to browbeat British insurer Prudential Plc (PRU.L) into raising its offer for AIG"s Asian unit by several billion dollars, according to two sources familiar with the situation.

Only a little over a year ago, Prudential had made a low-ball, oral bid for American International Assurance (AIA), offering a desperate AIG about $11 billion for the unit, the sources said.

But the Federal Reserve Bank of New York, with Morgan Stanley (MS.N) at its side, made an aggressive call at the height of the financial crisis -- that AIA and American Life Insurance Co (Alico), another large foreign life unit, were worth more than what they could fetch in the market then.

It was a bet that"s paying off in spades now.

AIG, nearly 80 percent owned by the government, agreed this week to sell AIA to the British insurer for $35.5 billion in the largest insurance deal ever.

Now the insurer is hoping to wrap up talks with MetLife Inc (MET.N) to sell Alico for about $15 billion, the sources said, declining to be identified because these talks are not public.

Those numbers are billions of dollars more than the offers AIA and Alico were attracting as AIG tried to sell them off to pay back the government in the months after its September 2008 rescue, the source said.

The situation was so dire in early 2009 that "it looked like the world was ending," one of the sources said.

The New York Fed, AIG and MetLife declined to comment. Prudential was not immediately available after-hours on Wednesday.

DIRE STRAITS

In early 2009, in addition to Prudential"s offer, AIG had two other bids in the $11 billion to $15 billion range for AIA, the sources said.

The bidders, however, had done no due diligence, and so even these offers were expected to be adjusted downward, one of these sources said.

For Alico, the bids were similarly low. MetLife"s bid at that time was around $11 billion, but it wanted the government to guarantee all investment assets, the sources said.

Axa SA (AXAF.PA) had offered in the $6 billion range, but the seriousness of its bid was suspect, they said.

New York Fed staff, AIG executives and their advisers knew they needed to find a way to buy time for markets to heal and to prepare the companies for separation, a third source said.

Over a series of meetings in lower Manhattan in January 2009, they came up with the idea of the special purpose vehicle, the source said.

"There was a recognition that they were good companies, but with the markets being as they were, they needed time," the source said.

The New York Fed said on March 2, 2009, it would take a $16 billion preferred stake in a vehicle that would hold AIA and a $9 billion preferred interest in a vehicle that would hold Alico, reducing AIG"s outstanding debt under a credit facility by that amount and giving the insurer more time to sell.

The Fed believed those units were worth more, and in coming up with the size of the preferred interest it left a cushion to give itself room to maneuver, one of the sources said.

FED MOVE HELPS

The Fed"s move helped AIG, which had been bailed out with a $182.3 billion taxpayer-funded aid package, on several fronts, the two sources said.

The debt-to-equity swap gave AIG a much-needed capital boost after a $61.7 billion loss in the fourth quarter of 2008, the largest ever quarterly loss in U.S. corporate history.

The Fed"s interest also set price floors for those businesses and gave AIG time to pursue other options, including initial public offerings, which in deals of this magnitude is as good as having a competitive auction, the sources said.

AIG got negotiating leverage, they said.

That allowed Benmosche, with Citigroup Inc (C.N) and Goldman Sachs (GS.N) also advising him, over a few weeks to get Prudential to raise its offer, which was already far above what AIG could have hoped to get during the dark days of the crisis, the sources said.

Blackstone Group (BX.N) advised AIG throughout the process.

It was a welcome turnaround for Benmosche who just months ago was threatening to leave the company over a bitter spat about compensation for AIG"s top executives.

In the end, AIG, used to having its own finances dissected, found itself scrutinizing Prudential"s ability to pull off such a massive deal, the sources said.

Last Friday, Prudential Chief Executive Tidjane Thiam, accompanied by JPMorgan Chase Co (JPM.N) CEO Jamie Dimon and Credit Suisse (CSGN.VX) CEO Brady Dougon, gave a presentation to convince AIG of its ability to do the deal, one source said.

By Monday, Benmosche was able to strike a deal that would help the government recover billions of its rescue funds.

Deals

Sunday, August 1, 2010

How 100000 are forced to retire at 65

Michelle Mitchell

"Wrong": Michelle Mitchell, director of Age Concern, said iorkers have should not have "expiry dates" when they hit 65

More than 100,000 workers were forced to retire against their will last year because they had reached their 65th birthday, research reveals today.

The findings highlight the nightmare facing workers in their sixties who cannot afford to stop working - but are told to by their bosses.

Charity Age Concern and Help the Aged, which funded the research, said it was wrong that older workers were given "an expiry date".

At present, a boss can get rid of any worker once they reach the age of 65, which is Britain"s "default retirement age."

The charity"s research, published today, exposes the dire consequences which this is causing for a generation of workers who desperately need to keep on earning.

With poor pensions, no savings and large mortgages, millions have no choice but to carry on.

Michelle Mitchell, a director of the charity said that "forced retirement" has become a major problem.

It predicts the problem will escalate, with around 250,000 workers aged 60 to 64 fearing that they are "likely or certain" to be booted out on or after their 65th birthday.

Nine in ten people in their 60s said they "oppose" forced retirement, and want to be able to carry on working if they choose to do so.

She said: "Our survey clearly shows the use of forced retirement has spiralled out of control.

"It offers some employers a low-cost shortcut to shed jobs during the recession." It is calling for the default retirement age to be scrapped.

More...Pensioners pay 450m too much in tax because HMRC "leaves them confused"

A Government review into the controversial subject has just ended, and a decision is expected later in the year. It is widely expected to be abolished it.

The financial pressure on people in their 60s is extreme given the huge social changes in recent years.

Many are men who have young families from their second marriage, which means they are still facing the huge cost of raising school-age children.

Others have elderly parents who are a burden on their finances, such as paying their care home fees. Many people have both elderly parents and young children, dubbed the "sandwich generation."

One in five people over the age of 55 still have a mortgage, including a shocking six per cent of people over the age of 75, according to the insurance giant Aviva.

Official figures show a record number of people who have reached state pension age, currently 65 for men and 60 for women, are working.

More than 1.4million pensioners have jobs, but there are many more who need to work but struggle to find a job.

Tom McPhail, head of pensions research at the financial advisers Hargreaves Lansdown, said: "The reality is that most people simply cannot afford to retire."

He urged people to "save as much as you can as soon as you can", although many workers cannot afford to follow such sensible advice.

A recent survey, from the Chartered Institue of Personnel and Development, found 70 per cent of workers aged 55 and above said the financial crisis leaves them with no option but to shelve their retirement plans.

Some business leaders fear that the move would be disastrous, and leave them with an elderly workforce which would "bedblock" the chance to hire younger, cheaper workers.